Adverse effects of Typbar-typhoid conjugated vaccine in children vaccinated in university of Lahore teaching hospital

Authors

  • Mahwish Ejaz
  • Muhammad Naveed
  • Muhammad Bilal Safdar Khawaja Muhammad Safdar Medical College
  • Mujahid Razzaq
  • Anum Tahir
  • Professor Dr. Ahsan Waheed Rathore

DOI:

https://doi.org/10.59058/jaimc.v21i4.125

Keywords:

Conjugate vaccine, adverse effect, Enteric fever

Abstract

Background and Objectives: Rising incidence of XDR enteric fever in Pakistan requires extensive workup on safe availability of immunization. Aim of this study was to assess the frequency of adverse effects of Typbar TCV in children vaccinated in a tertiary care facility.
Methods: It was a descriptive study in which children aged 9 months to 15 years of age either gender coming for vaccination to paediatric opd from 1st Feb-2021 to 17th Feb-2021 were included. Post vaccination observation for 30 minutes was done for all children in hospital and were followed after 14 days on telephone for any local or systemic adverse effect after vaccination. Complications (systemic and local) were documented on proforma. All data were analyzed using SPSS 22.
Results: In our study, total 835 children were enrolled out of which 666 responded. Contact with 169 children was not possible because their lack of response and unavailability. Mean age was 4.9±4.06 years. Regarding local adverse effects, pain at site of injection was present in 30% children. Other local site reaction includes swelling in 17.7%, redness in 3% and limitation of movement in 2.4%. Systemic adverse effects included fever in 20.4%. Headache was present in 0.6% children, GI symptoms present in 0.9%.
Conclusion: With Typbar-TCV Typhoid Vi conjugate vaccine. fever, pain and local reactogenicity were the most common side effects. Safety profile of TCV can further be assessed with the help of large multi centre trials So Tybar –TCV Typhoid Vi conjugate vaccine can be encouraged to administered safely to all children as the incidence of XDR typhoid is rising.
Key Word: Conjugate vaccine, adverse effect, Enteric fever

 

Downloads

Published

03-05-2024

How to Cite

Mahwish Ejaz, Muhammad Naveed, Safdar, M. B., Mujahid Razzaq, Anum Tahir, & Prof Dr. Ahsan Waheed Rathore. (2024). Adverse effects of Typbar-typhoid conjugated vaccine in children vaccinated in university of Lahore teaching hospital. JAIMC: Journal of Allama Iqbal Medical College, 21(4). https://doi.org/10.59058/jaimc.v21i4.125