Adverse effects of Typbar-typhoid conjugated vaccine in children vaccinated in university of Lahore teaching hospital
DOI:
https://doi.org/10.59058/jaimc.v21i4.125Keywords:
Conjugate vaccine, adverse effect, Enteric feverAbstract
Background and Objectives: Rising incidence of XDR enteric fever in Pakistan requires extensive workup on safe availability of immunization. Aim of this study was to assess the frequency of adverse effects of Typbar TCV in children vaccinated in a tertiary care facility.
Methods: It was a descriptive study in which children aged 9 months to 15 years of age either gender coming for vaccination to paediatric opd from 1st Feb-2021 to 17th Feb-2021 were included. Post vaccination observation for 30 minutes was done for all children in hospital and were followed after 14 days on telephone for any local or systemic adverse effect after vaccination. Complications (systemic and local) were documented on proforma. All data were analyzed using SPSS 22.
Results: In our study, total 835 children were enrolled out of which 666 responded. Contact with 169 children was not possible because their lack of response and unavailability. Mean age was 4.9±4.06 years. Regarding local adverse effects, pain at site of injection was present in 30% children. Other local site reaction includes swelling in 17.7%, redness in 3% and limitation of movement in 2.4%. Systemic adverse effects included fever in 20.4%. Headache was present in 0.6% children, GI symptoms present in 0.9%.
Conclusion: With Typbar-TCV Typhoid Vi conjugate vaccine. fever, pain and local reactogenicity were the most common side effects. Safety profile of TCV can further be assessed with the help of large multi centre trials So Tybar –TCV Typhoid Vi conjugate vaccine can be encouraged to administered safely to all children as the incidence of XDR typhoid is rising.
Key Word: Conjugate vaccine, adverse effect, Enteric fever
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Mahwish Ejaz, Muhammad Naveed, Muhammad Bilal Safdar, Mujahid Razzaq, Anum Tahir, Professor Dr. Ahsan Waheed Rathore
This work is licensed under a Creative Commons Attribution 4.0 International License.
The articles published in this journal come under creative commons licence Attribution 4.0 International (CC BY 4.0) which allows to copy and redistribute the material in any medium or format Adapt — remix, transform, and build upon the material for any purpose, even commercially under following terms.
-
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
The editorial board of the Journal strives hard for the authenticity and accuracy of the material published in the Journal. However, findings and statements are views of the authors and do not necessarily represent views of the Editorial Board. Many software like (Google Maps, Google Earth, Biorender (free version)) restricts the free distribution of materials prepared using these softwares. Therefore, authors are strongly advised to check the license/copyright information of the software used to prepare maps/images. In case of publication of copyright material, the correction will be published in one of the subsequent issues of the Journal, and the authors will bear the printing cost.