HISTOPATHOLOGICAL FEATURES IN RELAPSE OF ULCERATIVE COLITIS.
DOI:
https://doi.org/10.59058/jaimc.v20i4.59Keywords:
Ulcerative colitis, relapse, histopathological featuresAbstract
Background and objective: To determine the frequencies of various histopathological features of relapse in previously diagnosed cases of ulcerative colitis .
Methods: This was a Cross sectional study conducted at Histopathology department of Sheikh Zayed hospital Lahore from 1/6/2014 to 1/12/2014. Two hundred and seventy colonic biopsies were assessed using 3% margin of error and 95% of the confidence level. Patients clinically relapsed with ulcerative colitis including both genders in age group from 11 to 80 years were included. Biopsy specimen fixed in 10% formalin were received. Processing was done and sections stained with hematoxylin and were examined by the pathologist. College of Physicians and Surgeons Pakistan gave approval for this study. Data was then analyzed and entered by the SPSS version15.
Results: Total number of patients were 270,out of which all of the patients have shown chronic inflammation and increase number of neutrophils in lamina propria (100%), focal lymphoid aggregate in 162/270(60%), increased number of eosinophils in lamina propria in 108/270(40%), cryptitis in 216/270(80%), crypt distortion in 202/270(75%), mucin depletion in151/270 (56%) and crypt abscess formation in 148/270(55%).
Conclusion: Hence, cryptitis and crypt abscess were observed to be most commonly occurring significant and reliable featuress of relapse in ulcerative colitis.
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Bessissow T, Lemmens B, Ferrante M, Bisschops R, Van Steen K, Geboes K, Van Assche G, Vermeire S, Rutgeerts P, De Hertogh G. Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing. Am J Gastroenterol. 2012 Nov; 107(11):1684-92.
Toyonaga T, Saito E, Hisamatsu T, Hibia .Histological Risk Factors to Predict Clinical Relapse in Ulcerative. Journal of Crohn's and Colitis, 2018, 1288–1294
Narang V, kaur R, Garg B, Mahajan R, Midha R, Sood N. Association of endocopic and histological remission with clinical course in patients of ulcerative colitis. Intest Res.2018 Jan 16(1)55.61
Hussainy AS, Jafri W, Sheikh H .A Histopathological study comparing western and Pakistani Idiopathic Ulcerative Colitis. Pak J Pathol 1991; 2(1):23-7.
Azad S, Sood N and Sood A. Biological and histological parameters as predictors of relapse in ulcerative colitis. Saudi J Gastroenterol 2011; 17:194-8.
Ozaki R, Kobayashi T, Okabayashi S, Nakano M, Morinaga S, Hara A, Ohbu M, Matsuoka K, Toyonaga T, Saito E, Hisamatsu T, Hibi T. Histological Risk Factors to Predict Clinical Relapse in Ulcerative Colitis With Endoscopically Normal Mucosa. J Crohns Colitis. 2018 Nov 15; 12
Dhakhwa R1 , Shrestha HG2 , Acharya IL3. Histopathological evaluation of ulcerative colitis in colonoscopic biopsies. Journal of Pathology of Nepal 2016; Vol. 6, 932-936
Shah SN, Amarapurkar AD, Shrinivas N, Rathi PM. Atypical histological features of ulcerative colitis. Trop Gastroenterol 2011; 32(2):107-11.
Ardizzone S. Ulcerative colitis. Orphanet encyclopedia. September 2003; 6-7.
Khan S, Ahmed S, Shabbir G, Rahman SU. Frequency of ulcerative colitis in patients with bloody diarrhea. Khyber teaching hospital, Peshawar, Pakistan. Gonmal Journal of Medical Science. 2010, Vol.8, No2—28.
Kim YG, Jang BI. The Role of Colonoscopy in Inflammatory Bowel Disease. Clin Endosc.2013 July; 46(4):317-320
Viela EG, Torres HO, Martins FP. Evaluation of inflammatory activity in crohn’s disease and ulcerative colitis. World J Gastroenterol 2012 Mar 718(9); 872-81.
Histomorphological Diagnosis of Ulcerative Colitis and Associated Conditions. In: Pal, P. , editor. Ulcerative Colitis - Etiology, Diagnosis, Diet, Special Populations, and the Role of Interventional Endoscopy [Working Title] [Internet]. London: IntechOpen; 2022 [cited 2022 Nov
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